Pulmonary Arterial Hypertension is one of the rarest types of hypertension. It only occurs to 50 people out of a million. It is caused by the thickening and the narrowing of the pulmonary arteries which makes it difficult for blood to reach the lungs. Due to this condition, the heart gets overworked and the lungs still do not get the sufficient amounts of oxygen making the affected person weak. Pulmonary Hypertension can be a hereditary or inherited from a family trait or gene mutation. It can also be a result of illegal drug use such as cocaine, amphetamines, and meth but the most common cause of it is complications from other underlying diseases. HIV infection, liver disease, congenital heart disease, scleroderma, lupus, and anemia are some of the diseases where Pulmonary Hypertension usually stems from if not treated properly.
People with this kind of condition usually detect it when it’s already too late. Symptoms like shortness of breath, chest pains, swelling in joints, fatigue, fainting, heart palpitations and edema (bluish color of lips and skin) are already late-stage symptoms which means that the Pulmonary Hypertension has already developed in an advanced stage. The early stages of this condition are impossible to detect because currently, there is no technology available for detecting Pulmonary Hypertension when it’s only in its beginning phase.
Thankfully, Sildenafil has been developed and although its primary use was for Erectile Dysfunction, it can also be used for treating Pulmonary Arterial Hypertension.
First manufactured by Pfizer as the brand Viagra and Revatio, Sildenafil is also known for its property as a vasodilator, a drug that dilates the blood vessels. Sildenafil is an inhibitor of the enzyme in the body called PDE 5 or Phosphodiesterase type 5 which is responsible for keeping the normal pressure on the blood vessels. Inhibiting this enzyme loosens the blood vessels allowing larger amounts of blood to be circulated around the body.
Sildenafil Pulmonary Hypertension Mechanism of Action
Sildenafil provides relief to the patient by dilating the narrow arteries which will allow blood to pass fluidly from the heart to the lungs. This will now give the lungs proper amounts of oxygen, making the patient stronger. Since the blood can now flow easily, the heart’s muscles will now be relaxed and the blood pressure will be normalized causing an overall relief. Patients will PAH are still not allowed to engage in rigorous physical activities but they will now be able to accomplish more physical tasks compared when they were not on Sildenafil medication. The effects of Sildenafil are only temporary so the patient must take another dose as the drug wears out (4 hours) to keep the body’s normal functions.
Sildenafil Dose in Pulmonary Hypertension in Neonates
Babies (neonates) are born with high blood pressure in their lungs and it usually normalizes as the infant breathes air for the first time. But in some cases, even after the normal breathing has been established for the baby, the blood pressure remains high and as a result, the blood is unable to properly reach the lungs to get sufficient amounts of oxygen for the body.
These cases are called Persistent Pulmonary Hypertension of the Neonate (PPHN). If left untreated, it will develop high blood pressures in the lung blood vessels which will result to less delivery of oxygen to the different organs in the body of the infant and may eventually lead to early death. Sildenafil is used by the doctors in this condition to reduce the high blood pressure buildup in the infant’s lungs, making it normal by the dilation of the blood vessels inside their body. The exact dosage administered by the doctors in this scenario was never mentioned but since these are infants, it’s only at the levels that their bodies can tolerate.
Sildenafil Maximum Dosage
Pulmonary Hypertension, unlike Erectile Dysfunction, only needs small dosages of Sildenafil taken at three separate occasions in a day with 4 hours interval between doses. This is to keep Pulmonary Hypertension in check and to continuously provide the patient relief. Sildenafil does not cure Pulmonary Hypertension since it only alleviates the symptoms being experienced by the patient. The maximum dosage that a patient can take in a single dose is 20mg. Depending on the intensity of the ailment and the patient’s tolerance for the drug, the doctor may only recommend smaller dosages.
Sildenafil use does come with side-effects and the common ones are headaches, dizziness, stomach upset, flushing, back pains, muscle pains, chest pains, nausea, and vomiting. These side effects only occur as the body adjusts to the medication and will disappear with constant use. Side effects are likely to appear with large doses of the drug but since only small doses of Sildenafil is required for Pulmonary Hypertension, side effect occurrences will only be minimal.
How to Buy the Product Online
Sildenafil is available at most drugstores online but the ones that are used for PAH are the ones with dosages of 20mg and below. The dosages of Sildenafil which are from 50mg and above are only used for Erectile Dysfunction and are only taken once a day. To have an easy time shopping for your medicines online, check our Top List of Recommended Pharmacies where it’s guaranteed safe and the products are of high quality.
PAH is a serious condition that needs immediate medical attention. Sildenafil is the most effective medication to treat this anomaly in the body and it works by dilating the narrow arteries that prevent the blood from flowing freely from the heart to the lungs. Infants are also prone to having this condition and Sildenafil is also the drug to be used for its treatment. Sildenafil can be purchased locally but cheaper prices are offered at the List of Recommended Pharmacies.